Widely-distributed throughout the Amazon, Orinoco, Essequibo, and Tocantins river systems in Brazil, Peru, Bolivia, Ecuador, Colombia, Venezuela, and Guyana.

Type locality is ‘Rio Cupai [= Rio Cupari], Rio Tapajós basin, Amazon River drainage, Pará State, Brazil’.

C. guapore is a sought after aquarium fish although it is not often traded. It exhibits slightly different behaviour to the majority of congeners in that it tends to form aggregations in midwater and spends a large proportion of its time away from the substrate. Its morphology exhibits corresponding adaptations towards a pelagic existence with a relatively large eye, a more terminal mouth position, more strongly-forked caudal-fin, and more symmetrical body shape than most other Corydoras species.

The majority of records pertain to the rio Guaporé (Río Iténez in Bolivia), the main affluent of the rio Mamoré, which drains the vast tropical wetland known as the Pantanal, and the upper rio Paraguai, which also has its headwaters in the Pantanal but flows in the opposite direction. The Guaporé and Paraguai are connected due to rising water levels during the annual wet season.