It exhibits slightly different behaviour to the majority of congeners in that it tends to swim in midwater and spends a large proportion of its time away from the substrate. Its morphology exhibits corresponding adaptations towards a pelagic existence with a relatively large eye, a more terminal mouth position, more strongly-forked caudal-fin, and more symmetrical body shape than most other Corydoras species.

Famed as a rapacious predator capable of rapidly stripping flesh from bone and a danger to any animal entering its native waters, P. nattereri is among the most notorious freshwater fishes in the world. As a result, displays featuring this “bloodthirsty” creature are found in most public aquaria, grisly Hollywood movies have been released, and the species has become popular in the aquarium trade. Little of this infamy is based on factual evidence, however.